In this time of cynicism and hopelessness, I reach back to when my son, former Marine Corporal Gav Jacobs, met one of his idols, Sen. John McCain. It was 2008, and my son was at Balboa Navy Hospital in San Diego learning to walk with his new prosthetic leg. Like McCain, my son’s life was […]
Reported by Seattle Times 1 day ago.
Sen. John McCain: Meeting an idol
↧
↧
Longtime Port of Kalama Deputy Auditor Retires
The Port bids a warm farewell to Linda Durgeloh Williams, the longest acting employee at the Port with 45 years of service
KALAMA, Wash. (PRWEB) August 31, 2018
Port of Kalama today bids a warm farewell to its longest serving employee, deputy auditor Linda Durgeloh Williams. Williams, who has worked at the Port for 45 years, started as a relief secretary in 1973 and worked her way up to deputy auditor where she managed payroll, accounts payable and receivables and employee benefits among other duties related to marine terminal operations.
Williams’ role and responsibilities will be split up among the current financial services and marine terminal operations teams at the Port.
“I changed my plans to pursue teaching when I was offered an incredible opportunity to stay in my home town of Kalama working for the Port—then a team of one manager and two part-time employees,” says Williams. “The changes we’ve seen here at the Port have been incredible—adding recreational value and distinction and economic vitality to the entire community. I have been so honored to be a part of the growth and change here.”
Williams has witnessed some big moments during her tenure. She saw the raising of the Totem Pole in 1974, the development of the North Port from a cow pasture into an industrial park, a dock and corporate headquarters for Steelscape. She has seen the Oak Street overpass constructed and the installment of pedestrian and bike pathways throughout the Port. Most impressively, she has witnessed the Port's expansion from one to three operating docks and a roster that includes 18 full-time employees. A highlight that stands out for Linda is her ride on a navy ship from Astoria to the Portland Rose Festival.
“The commission cannot thank Linda enough for dedicating her career to the Port—she has been indispensable to the organization in so many ways and has grown incredibly during her tenure,” said Alan Basso, Port of Kalama Commissioner. “Linda has managed so many aspects of the financial services department and taken on new roles as needed—from marine terminal operations to hiring longshoremen! She will be missed incredibly.”
About Port of Kalama – Where rail and water meet
The Port of Kalama is located in Southwest Washington on the Columbia River and immediately off of Interstate Highway 5. The port exists to induce capital investment in an environmentally responsible manner to create jobs and to enhance public recreational opportunities. Port of Kalama's industrial area includes five miles of riverfront property adjacent to the 43' federally-maintained deep draft navigation channel of the Columbia River. The Port is served by the Burlington Northern/Santa Fe and Union Pacific railroads. There are over 30 businesses located at the Port of Kalama, employing over 1,000 people. Port of Kalama offers all the superior facilities businesses need to thrive, and an unsurpassed quality of life. The port offers shovel ready sites, a new Industrial Park, state of the art Marine Terminals and transportation accessibility to rail and highway all just a 30-minute drive to the Portland International Airport. Port of Kalama also offers high-bandwidth communications, with dual access fiber-optic service to Seattle and Portland. Properties currently available at the port for businesses wishing to expand and thrive: Visit http://portofkalama.com/available-properties/.
Contact: Liz Newman, marketing manager, Port of Kalama, 360-673-2379 or Claudia Johnson, PR, 503-799-2220. Reported by PRWeb 1 day ago.
KALAMA, Wash. (PRWEB) August 31, 2018
Port of Kalama today bids a warm farewell to its longest serving employee, deputy auditor Linda Durgeloh Williams. Williams, who has worked at the Port for 45 years, started as a relief secretary in 1973 and worked her way up to deputy auditor where she managed payroll, accounts payable and receivables and employee benefits among other duties related to marine terminal operations.
Williams’ role and responsibilities will be split up among the current financial services and marine terminal operations teams at the Port.
“I changed my plans to pursue teaching when I was offered an incredible opportunity to stay in my home town of Kalama working for the Port—then a team of one manager and two part-time employees,” says Williams. “The changes we’ve seen here at the Port have been incredible—adding recreational value and distinction and economic vitality to the entire community. I have been so honored to be a part of the growth and change here.”
Williams has witnessed some big moments during her tenure. She saw the raising of the Totem Pole in 1974, the development of the North Port from a cow pasture into an industrial park, a dock and corporate headquarters for Steelscape. She has seen the Oak Street overpass constructed and the installment of pedestrian and bike pathways throughout the Port. Most impressively, she has witnessed the Port's expansion from one to three operating docks and a roster that includes 18 full-time employees. A highlight that stands out for Linda is her ride on a navy ship from Astoria to the Portland Rose Festival.
“The commission cannot thank Linda enough for dedicating her career to the Port—she has been indispensable to the organization in so many ways and has grown incredibly during her tenure,” said Alan Basso, Port of Kalama Commissioner. “Linda has managed so many aspects of the financial services department and taken on new roles as needed—from marine terminal operations to hiring longshoremen! She will be missed incredibly.”
About Port of Kalama – Where rail and water meet
The Port of Kalama is located in Southwest Washington on the Columbia River and immediately off of Interstate Highway 5. The port exists to induce capital investment in an environmentally responsible manner to create jobs and to enhance public recreational opportunities. Port of Kalama's industrial area includes five miles of riverfront property adjacent to the 43' federally-maintained deep draft navigation channel of the Columbia River. The Port is served by the Burlington Northern/Santa Fe and Union Pacific railroads. There are over 30 businesses located at the Port of Kalama, employing over 1,000 people. Port of Kalama offers all the superior facilities businesses need to thrive, and an unsurpassed quality of life. The port offers shovel ready sites, a new Industrial Park, state of the art Marine Terminals and transportation accessibility to rail and highway all just a 30-minute drive to the Portland International Airport. Port of Kalama also offers high-bandwidth communications, with dual access fiber-optic service to Seattle and Portland. Properties currently available at the port for businesses wishing to expand and thrive: Visit http://portofkalama.com/available-properties/.
Contact: Liz Newman, marketing manager, Port of Kalama, 360-673-2379 or Claudia Johnson, PR, 503-799-2220. Reported by PRWeb 1 day ago.
↧
Exploring Delaware's Inland Bays
The 32-square-mile Inland Bays watershed covering a portion of Sussex County is home to a variety of marine life and supports a vibrant boating and fishing industry.
Reported by Delawareonline 23 hours ago.
Reported by Delawareonline 23 hours ago.
↧
Records: More than 40 pipe bombs found in Arizona man’s home
MESA, Ariz. (AP) — A former Marine told authorities he kept a cache of more than 40 pipe bombs in his Arizona home to please his wife, who believed they would be needed if the U.S. government collapsed, according to court documents released Friday. Jeffrey Dennis Metcalf, 51, is facing 40 counts of manufacturing, selling […]
Reported by Seattle Times 22 hours ago.
↧
Records: More than 40 pipe bombs found in Arizona man's home
A former Marine told authorities he kept a cache of more than 40 pipe bombs in his Arizona home to please his wife, who believed they would be needed if the U.S. government collapsed, according to court documents released Friday.
Reported by FOXNews.com 22 hours ago.
↧
↧
Ben Lecomte: a 5,000 Mile Swim Across the Pacific
After becoming the first human to swim across the Atlantic in 1998, Ben Lecomte has taken on a new challenge: going from Tokyo to San Francisco, swimming 8 hours per day.
(PRWEB) August 31, 2018
Right this minute, Frenchman Ben Lecomte is hard at work on his second ocean crossing. After becoming the first human to swim across the Atlantic in 1998, he’s taken on a new challenge: going from Tokyo to San Francisco, churning his limbs eight hours a day in the cold Pacific for six months, accompanied by his team on the support boat. As the first expedition of its kind, The Swim is far more than just an extreme sport. Besides the gruelling physical challenge, Lecomte and his team will conduct scientific research in medicine and oceanography, led at a distance by NASA and the Woods Hole Oceanographic Institution. Crucially, the Swim doubles as a chance to engage people with a colossal issue — namely, the human impacts on the oceans. Lecompte will also set a new world record for endurance swimming when he steps ashore at the other end.
Montreal design, communication and digital marketing agency David&Goliath has been part of Lecomte’s team for two years. As well as developing the brand image, the agency created and produced the website and press kit, lending credibility to the extraordinary undertaking. The brand has since helped attract major partners to the adventure.
The big day dawned on June 5, when Lecomte donned his wetsuit and waded into the surf off the coast of Japan. Throughout the adventure, he’ll be monitored and supported by his team on board and, back on terra firma, by scientists, logistics specialists, doctors and other experts. Not only will they remotely track his physical condition, they can also accompany him as needed directly from the mainland. Back on the yacht, the crew will conduct oceanic and medical research for the duration of the trip, taking samples from the water as well as studying Lecomte’s performance.
FOR SCIENCE AND BEYOND THE OCEAN
The Swim will serve as a platform to draw attention to what is happening to our oceans. Overseeing the health and ocean research is a team of 12 scientists. It’s the first time a scientific endeavour of this scope will be able to examine the entire span of the Pacific. In particular, Lecomte’s route will take him through the Great Pacific Garbage Patch: the giant floating mass of plastic rubbish where pollution concentrations have already been measured at over a million pieces of microplastic per square kilometre. Through samples collected by the crew, researchers will learn more about the ages of these particles and the chemical mechanisms behind their creation. They will also study the microorganisms that have proliferated around the waste, measuring how they affect the surrounding ecosystem and assessing their potential for further multiplication.
Radioactive particles released during the Fukushima reactor disaster in 2011 continue to spread out and move westward, potentially posing a significant threat to the ocean floor. Lecomte and his team will collect valuable data on the position and movement of these particles, allowing scientists in turn to calculate their concentration. Other samples will shed light on ocean acidification rates and the adverse impacts of global warming on corals and marine life. The expedition will also measure the impact of gravity on the human body. Throughout the journey, satellite communications will let the crew stay connected and share their experience. Viewers can chart Lecomte’s progress an interactive map, which also shows the weather conditions. Updated content will be regularly posted at http://benlecomte.com/. Join the adventure! Reported by PRWeb 22 hours ago.
(PRWEB) August 31, 2018
Right this minute, Frenchman Ben Lecomte is hard at work on his second ocean crossing. After becoming the first human to swim across the Atlantic in 1998, he’s taken on a new challenge: going from Tokyo to San Francisco, churning his limbs eight hours a day in the cold Pacific for six months, accompanied by his team on the support boat. As the first expedition of its kind, The Swim is far more than just an extreme sport. Besides the gruelling physical challenge, Lecomte and his team will conduct scientific research in medicine and oceanography, led at a distance by NASA and the Woods Hole Oceanographic Institution. Crucially, the Swim doubles as a chance to engage people with a colossal issue — namely, the human impacts on the oceans. Lecompte will also set a new world record for endurance swimming when he steps ashore at the other end.
Montreal design, communication and digital marketing agency David&Goliath has been part of Lecomte’s team for two years. As well as developing the brand image, the agency created and produced the website and press kit, lending credibility to the extraordinary undertaking. The brand has since helped attract major partners to the adventure.
The big day dawned on June 5, when Lecomte donned his wetsuit and waded into the surf off the coast of Japan. Throughout the adventure, he’ll be monitored and supported by his team on board and, back on terra firma, by scientists, logistics specialists, doctors and other experts. Not only will they remotely track his physical condition, they can also accompany him as needed directly from the mainland. Back on the yacht, the crew will conduct oceanic and medical research for the duration of the trip, taking samples from the water as well as studying Lecomte’s performance.
FOR SCIENCE AND BEYOND THE OCEAN
The Swim will serve as a platform to draw attention to what is happening to our oceans. Overseeing the health and ocean research is a team of 12 scientists. It’s the first time a scientific endeavour of this scope will be able to examine the entire span of the Pacific. In particular, Lecomte’s route will take him through the Great Pacific Garbage Patch: the giant floating mass of plastic rubbish where pollution concentrations have already been measured at over a million pieces of microplastic per square kilometre. Through samples collected by the crew, researchers will learn more about the ages of these particles and the chemical mechanisms behind their creation. They will also study the microorganisms that have proliferated around the waste, measuring how they affect the surrounding ecosystem and assessing their potential for further multiplication.
Radioactive particles released during the Fukushima reactor disaster in 2011 continue to spread out and move westward, potentially posing a significant threat to the ocean floor. Lecomte and his team will collect valuable data on the position and movement of these particles, allowing scientists in turn to calculate their concentration. Other samples will shed light on ocean acidification rates and the adverse impacts of global warming on corals and marine life. The expedition will also measure the impact of gravity on the human body. Throughout the journey, satellite communications will let the crew stay connected and share their experience. Viewers can chart Lecomte’s progress an interactive map, which also shows the weather conditions. Updated content will be regularly posted at http://benlecomte.com/. Join the adventure! Reported by PRWeb 22 hours ago.
↧
Cape Cod beaches: Playgrounds for tourists, and young sharks
BOSTON (AP) — A prominent shark researcher says smaller, younger great white sharks are being spotted in larger numbers off Cape Cod. Massachusetts marine biologist Greg Skomal says the presence of juvenile sharks could be contributing to more encounters with humans because the young sharks tend to favor the large fish anglers also prize. Cape Cod authorities, meanwhile, worry about what happens after Labor Day, when lifeguards leave. The National Park Service says beach closures from shark sightings have more than doubled this year, and a 61-year-old New York man was severely injured after a shark bit his leg Aug. 15 off Cape Cod. The International Shark Attack File in Florida says the attack is among 37 worldwide this year.
Reported by SeattlePI.com 22 hours ago.
↧
FMO Announces Modifications to Certain Non-Fundamental Investment Policies and Name Change
NEW YORK, Aug. 31, 2018 (GLOBE NEWSWIRE) -- Fiduciary/Claymore MLP Opportunity Fund (NYSE: FMO) (the “Fund”) today announced that the Fund’s Board of Trustees (the “Board”) approved modifications to certain non-fundamental investment policies and the name of the Fund, which will become effective as of November 9, 2018.Investment Policy Changes
The Fund will continue to pursue its primary investment objective to provide a high level of after-tax total return with an emphasis on current distributions paid to shareholders.
Currently, under normal market conditions, the Fund invests at least 80% of its Managed Assets (as defined in the Prospectus) in master limited partnerships (“MLPs”) and MLP affiliates (“MLP Entities”) and invests at least 65% of its Managed Assets in equity securities of MLP Entities. A substantial portion of the MLP Entities in which the Fund invests are engaged primarily in the energy, natural resources and real estate sectors of the economy.
Effective November 9, 2018, under normal market conditions, the Fund will invest at least 80% of its Managed Assets in energy infrastructure MLPs and other energy infrastructure companies. The Fund considers an “energy infrastructure” MLP or company to be an MLP or company (i) engaged in the development, construction, distribution, management, ownership, operation and/or financing of energy infrastructure assets, including, but not limited to, assets used in exploration, development, production, generation, transportation (including marine), transmission, terminal operation, storage, gathering, processing, refining, distribution, mining, or marketing of natural gas, natural gas liquids, crude oil, refined petroleum products (including biodiesel and ethanol), coal or electricity or power generation, or that provides energy-related equipment or services, and that has at least 50% of its assets, income, sales or profits committed to or derived from energy infrastructure related assets or activities or (ii) that have been given a third party industry or sector classification consistent with the energy infrastructure designation. The Fund will invest at least 65% of its Managed Assets in equity securities of MLP entities energy infrastructure MLPs and other energy infrastructure companies.
No other changes to the Fund’s other investment policies or the Fund’s portfolio management team are currently anticipated, nor is it currently anticipated that there will be substantial portfolio turnover in conjunction with these changes in the immediate future.
No action is required by shareholders of the Fund in connection with these investment policy changes.
Name Change
In connection with the investment policy changes described herein, the Fund will be required to change its name. Upon the effective date, the Fund will change its name to “Fiduciary/Claymore Energy Infrastructure Fund”. The Fund’s ticker symbol and CUSIP will not change.
Additional Considerations
As a result of the investment policy changes described herein, the Fund will no longer be required to invest a specific percentage of its managed assets in MLPs and may invest without limitation in other energy infrastructure companies.
The Fund is treated as a regular corporation for U.S. federal income tax purposes and, as a result, unlike most investment companies, is subject to corporate income tax to the extent the Fund recognizes taxable income. Unlike MLPs, which are generally treated as partnerships for U.S. federal income tax purposes, non-MLP energy infrastructure companies in which the Fund invests are generally taxed as corporations. Such companies thus pay corporate-level taxes on their net taxable income and may not offer certain other advantageous tax characteristics of MLP investments.
For example, a significant portion of the distributions received by the Fund from the MLPs in which it invests have historically consisted of return of capital for U.S. federal income tax purposes. To the extent that the Fund increases its investments in non-MLP energy infrastructure companies, a greater portion of the distributions the Fund receives may consist of taxable income, which may result in the Fund having a larger corporate income tax expense, which may result in less cash available to distribute to Common Shareholders.
In addition, as a result of the character of the distributions received by the Fund from the MLPs in which it invests, historically a significant portion of the distributions made by the Fund to the holders of its common shares have consisted of return of capital for U.S. federal income tax purposes. To the extent that the Fund increases its investments in non-MLP energy infrastructure companies, a lesser percentage of future distributions by the Fund to holders of its common shares may be treated as a return of capital for U.S. federal income tax purposes and a greater percentage of future distributions may be treated as ordinary income.
Investments in non-MLP energy infrastructure companies are subject to equity securities risk, which is the risk that value of equity securities will fall due to general market or economic conditions, perceptions regarding the industries in which the issuers of such securities participate, changes in interest rates, and the particular circumstances and performance of particular issuers of such securities. Non-MLP energy infrastructure companies are also subject to energy sector risks and industry specific risks.
For the most up-to-date information and a more complete discussion of these and other risk considerations associated with an investment in the Fund, please visit the Fund’s website at guggenheiminvestments.com/FMO.
*Additional Information*
*The Fund*
The Fund is a non-diversified, closed-end management investment company that commenced investment operations on December 28, 2004. The Fund's investment objective is to provide a high level of after-tax total return with an emphasis on current distributions paid to shareholders.
*About Advisory Research*
Advisory Research, Inc. serves as Investment Sub-Adviser for the Fund and is not affiliated with Guggenheim. Advisory Research, Inc., a registered investment adviser, is a wholly-owned subsidiary of Piper Jaffray Companies. As of June 30, 2018, the MLP & Energy Infrastructure team (“MLP Team”) at Advisory Research, Inc. managed approximately $4.0 billion in MLP and energy infrastructure assets for open-end mutual funds, closed-end funds, public and corporate pension plans, endowments and foundations and private wealth individuals.
*About Guggenheim Investments*
Guggenheim Investments is the global asset management and investment advisory division of Guggenheim Partners, LLC (“Guggenheim”), with $208 billion* in assets under management across fixed income, equity, and alternative strategies. We focus on the return and risk needs of insurance companies, corporate and public pension funds, sovereign wealth funds, endowments and foundations, consultants, wealth managers, and high-net-worth investors. Our 300+ investment professionals perform rigorous research to understand market trends and identify undervalued opportunities in areas that are often complex and underfollowed. This approach to investment management has enabled us to deliver innovative strategies providing diversification opportunities and attractive long-term results.
*Assets under management is as of 06.30.2018 and includes leverage of $11.7bn. Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Real Estate, LLC, GS GAMMA Advisors, LLC, Guggenheim Partners Europe Limited and Guggenheim Partners India Management.
This information does not represent an offer to sell securities of the Fund and it is not soliciting an offer to buy securities of the Fund. There can be no assurance that the Fund will achieve its investment objective. Investments in the Fund involve operating expenses and fees. The net asset value of the Fund will fluctuate with the value of the underlying securities. It is important to note that closed-end funds trade on their market value, not net asset value, and closed-end funds often trade at a discount to their net asset value. Past performance is not indicative of future performance. An investment in the Fund is subject to investment risk, including the possible loss of the entire amount that you invest. Investing in the energy sector is susceptible to adverse global and domestic economic or regulatory occurrences affecting the sector and additional risks including: commodity price volatility; the risk of supply and demand variances; interest-rate risk; catastrophic event risk; and the possibility of resource depletion. See www.guggenheiminvestments.com/fmo for a detailed discussion of Fund-specific risks.
*Investors should consider the investment objectives and policies, risk considerations, charges and expenses of any investment before they invest. For this and more information, visit www.guggenheiminvestments.com or contact a securities representative or Guggenheim Funds Distributors, LLC 227 West Monroe Street, Chicago, IL 60606, 800-345-7999.*
*Analyst Inquiries*
William T. Korver
cefs@guggenheiminvestments.com
NOT FDIC-INSURED | NOT BANK-GUARANTEED | MAY LOSE VALUE
Member FINRA/SIPC (08/18) Reported by GlobeNewswire 22 hours ago.
The Fund will continue to pursue its primary investment objective to provide a high level of after-tax total return with an emphasis on current distributions paid to shareholders.
Currently, under normal market conditions, the Fund invests at least 80% of its Managed Assets (as defined in the Prospectus) in master limited partnerships (“MLPs”) and MLP affiliates (“MLP Entities”) and invests at least 65% of its Managed Assets in equity securities of MLP Entities. A substantial portion of the MLP Entities in which the Fund invests are engaged primarily in the energy, natural resources and real estate sectors of the economy.
Effective November 9, 2018, under normal market conditions, the Fund will invest at least 80% of its Managed Assets in energy infrastructure MLPs and other energy infrastructure companies. The Fund considers an “energy infrastructure” MLP or company to be an MLP or company (i) engaged in the development, construction, distribution, management, ownership, operation and/or financing of energy infrastructure assets, including, but not limited to, assets used in exploration, development, production, generation, transportation (including marine), transmission, terminal operation, storage, gathering, processing, refining, distribution, mining, or marketing of natural gas, natural gas liquids, crude oil, refined petroleum products (including biodiesel and ethanol), coal or electricity or power generation, or that provides energy-related equipment or services, and that has at least 50% of its assets, income, sales or profits committed to or derived from energy infrastructure related assets or activities or (ii) that have been given a third party industry or sector classification consistent with the energy infrastructure designation. The Fund will invest at least 65% of its Managed Assets in equity securities of MLP entities energy infrastructure MLPs and other energy infrastructure companies.
No other changes to the Fund’s other investment policies or the Fund’s portfolio management team are currently anticipated, nor is it currently anticipated that there will be substantial portfolio turnover in conjunction with these changes in the immediate future.
No action is required by shareholders of the Fund in connection with these investment policy changes.
Name Change
In connection with the investment policy changes described herein, the Fund will be required to change its name. Upon the effective date, the Fund will change its name to “Fiduciary/Claymore Energy Infrastructure Fund”. The Fund’s ticker symbol and CUSIP will not change.
Additional Considerations
As a result of the investment policy changes described herein, the Fund will no longer be required to invest a specific percentage of its managed assets in MLPs and may invest without limitation in other energy infrastructure companies.
The Fund is treated as a regular corporation for U.S. federal income tax purposes and, as a result, unlike most investment companies, is subject to corporate income tax to the extent the Fund recognizes taxable income. Unlike MLPs, which are generally treated as partnerships for U.S. federal income tax purposes, non-MLP energy infrastructure companies in which the Fund invests are generally taxed as corporations. Such companies thus pay corporate-level taxes on their net taxable income and may not offer certain other advantageous tax characteristics of MLP investments.
For example, a significant portion of the distributions received by the Fund from the MLPs in which it invests have historically consisted of return of capital for U.S. federal income tax purposes. To the extent that the Fund increases its investments in non-MLP energy infrastructure companies, a greater portion of the distributions the Fund receives may consist of taxable income, which may result in the Fund having a larger corporate income tax expense, which may result in less cash available to distribute to Common Shareholders.
In addition, as a result of the character of the distributions received by the Fund from the MLPs in which it invests, historically a significant portion of the distributions made by the Fund to the holders of its common shares have consisted of return of capital for U.S. federal income tax purposes. To the extent that the Fund increases its investments in non-MLP energy infrastructure companies, a lesser percentage of future distributions by the Fund to holders of its common shares may be treated as a return of capital for U.S. federal income tax purposes and a greater percentage of future distributions may be treated as ordinary income.
Investments in non-MLP energy infrastructure companies are subject to equity securities risk, which is the risk that value of equity securities will fall due to general market or economic conditions, perceptions regarding the industries in which the issuers of such securities participate, changes in interest rates, and the particular circumstances and performance of particular issuers of such securities. Non-MLP energy infrastructure companies are also subject to energy sector risks and industry specific risks.
For the most up-to-date information and a more complete discussion of these and other risk considerations associated with an investment in the Fund, please visit the Fund’s website at guggenheiminvestments.com/FMO.
*Additional Information*
*The Fund*
The Fund is a non-diversified, closed-end management investment company that commenced investment operations on December 28, 2004. The Fund's investment objective is to provide a high level of after-tax total return with an emphasis on current distributions paid to shareholders.
*About Advisory Research*
Advisory Research, Inc. serves as Investment Sub-Adviser for the Fund and is not affiliated with Guggenheim. Advisory Research, Inc., a registered investment adviser, is a wholly-owned subsidiary of Piper Jaffray Companies. As of June 30, 2018, the MLP & Energy Infrastructure team (“MLP Team”) at Advisory Research, Inc. managed approximately $4.0 billion in MLP and energy infrastructure assets for open-end mutual funds, closed-end funds, public and corporate pension plans, endowments and foundations and private wealth individuals.
*About Guggenheim Investments*
Guggenheim Investments is the global asset management and investment advisory division of Guggenheim Partners, LLC (“Guggenheim”), with $208 billion* in assets under management across fixed income, equity, and alternative strategies. We focus on the return and risk needs of insurance companies, corporate and public pension funds, sovereign wealth funds, endowments and foundations, consultants, wealth managers, and high-net-worth investors. Our 300+ investment professionals perform rigorous research to understand market trends and identify undervalued opportunities in areas that are often complex and underfollowed. This approach to investment management has enabled us to deliver innovative strategies providing diversification opportunities and attractive long-term results.
*Assets under management is as of 06.30.2018 and includes leverage of $11.7bn. Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Real Estate, LLC, GS GAMMA Advisors, LLC, Guggenheim Partners Europe Limited and Guggenheim Partners India Management.
This information does not represent an offer to sell securities of the Fund and it is not soliciting an offer to buy securities of the Fund. There can be no assurance that the Fund will achieve its investment objective. Investments in the Fund involve operating expenses and fees. The net asset value of the Fund will fluctuate with the value of the underlying securities. It is important to note that closed-end funds trade on their market value, not net asset value, and closed-end funds often trade at a discount to their net asset value. Past performance is not indicative of future performance. An investment in the Fund is subject to investment risk, including the possible loss of the entire amount that you invest. Investing in the energy sector is susceptible to adverse global and domestic economic or regulatory occurrences affecting the sector and additional risks including: commodity price volatility; the risk of supply and demand variances; interest-rate risk; catastrophic event risk; and the possibility of resource depletion. See www.guggenheiminvestments.com/fmo for a detailed discussion of Fund-specific risks.
*Investors should consider the investment objectives and policies, risk considerations, charges and expenses of any investment before they invest. For this and more information, visit www.guggenheiminvestments.com or contact a securities representative or Guggenheim Funds Distributors, LLC 227 West Monroe Street, Chicago, IL 60606, 800-345-7999.*
*Analyst Inquiries*
William T. Korver
cefs@guggenheiminvestments.com
NOT FDIC-INSURED | NOT BANK-GUARANTEED | MAY LOSE VALUE
Member FINRA/SIPC (08/18) Reported by GlobeNewswire 22 hours ago.
↧
Climate change, scorching summers bring more Southern fish to Delaware waters
Surrounded by some of the largest coastal estuaries on the East Coast, Delaware sees its fair share of varied marine life. Warmer waters are making it even more interesting.
Reported by Delawareonline 21 hours ago.
Reported by Delawareonline 21 hours ago.
↧
↧
Larson Electronics LLC Releases Explosion Proof Spray Paint Booth Light with Modbus Capabilities
KEMP, Texas, Aug. 31, 2018 (GLOBE NEWSWIRE) -- Industrial lighting leader, Larson Electronics LLC, has released an explosion proof LED paint spray booth light fixture that provides operators in hazardous environments powerful, energy efficient illumination and features Modbus TCP/IP network controller and Aevum Network Control Lighting Solution. This four-foot two-lamp fixture is rated for Class I Division 1 & 2 and Class II Division 1 & 2 areas, and holds paint spray booth, ATEX and IECEx certifications, making it ideal for paint booths, oil rigs, offshore applications, petrochemical, manufacturing, chemical storage and more.The EPL-ANC-48-2L-LED explosion proof LED fixture provides 7,000 lumens of high quality light drawing just 56 watts. This two-lamp explosion proof LED linear fixture is lighter in weight, has a slimmer profile, and produces more light than traditional explosion proof fluorescent fixtures. The four-foot-long T6 LED tube design bulbs included with this unit are rated at 50,000 hours of service life, which is over twice as long as standard T8 bulbs. This LED produces a 150º degree beam spread and has a standard 5600K cool white color temperature to produce colors and details more accurately than traditional luminaries.
The EPL-ANC-48-2L-LED allows operators to setup remote access, controls and configurations with the inclusion of Modbus TCP/IP network controller via a standard web browser. The network controller is equipped with one optically-isolate digital input and one SPDT relay contact. The unit is compatible with 9-28V DC and has a 3-position removeable relay, a 5-position removable power/inputs and an 8-pin RJ-45 port for network connections.
Aevum Network Controlled Lighting Solution enables connected and intelligent illumination using cutting-edge and existing networks using Modbus TCP/IP or DALI, allowing operators to control lights and sensors remotely. The status of fixtures can also be monitored remotely with this platform reducing maintenance and downtimes.
This lightweight low-profile explosion proof LED is compact and built with extruded aluminum. The fixture is Marine approved and NEMA 4X and IP67 rated, making it dust-proof and protected against high pressure jets and temporary submersion, as well as resistant to vibration and impacts.
The EPL-ANC-48-2L-LED is offered with suspension pendant mounting or surface mounting options. This light is universal voltage and can operate on any voltage from 120V to 277V AC 50/60Hz without modifications. There is no ballast in this unit and the included LED lamps have a 50,000+ hour service life, both of which result in extreme efficiency and greatly reduced maintenance costs.
“This LED fixture provides reliable, durable and safe power to hazardous locations, with maximum efficiency due to the third generation LEDs, and reliable network connectivity,” said Rob Bresnahan, CEO of Larson Electronics LLC. “The Modbus network capability allows operators to setup various control and configurations including remote access.”
*About Larson Electronics LLC:* Larson Electronics LLC is a manufacturer of industrial lighting equipment and accessories. The company offers an extensive catalog of industry-grade lighting and power distribution products for the following sectors: manufacturing, construction, food processing, oil and gas, military, marine and automobile. Customers can benefit from the company’s hands-on, customized approach to lighting solutions. Larson Electronics provides expedited service for quotes, customer support and shipments.
*For further information, please contact:*
Rob Bresnahan, *President and CEO
*Toll-free: 1-800-369-6671
Phone: 214-616-6180
Fax: 903-498-3364
E-mail: sales@larsonelectronics.com
Photos accompanying this announcement are available at
http://www.globenewswire.com/NewsRoom/AttachmentNg/4cd8c1c4-4d5c-4a91-90bc-222677c49027
http://www.globenewswire.com/NewsRoom/AttachmentNg/a74556f4-1626-457b-8428-044037b0407f
Reported by GlobeNewswire 22 hours ago.
The EPL-ANC-48-2L-LED allows operators to setup remote access, controls and configurations with the inclusion of Modbus TCP/IP network controller via a standard web browser. The network controller is equipped with one optically-isolate digital input and one SPDT relay contact. The unit is compatible with 9-28V DC and has a 3-position removeable relay, a 5-position removable power/inputs and an 8-pin RJ-45 port for network connections.
Aevum Network Controlled Lighting Solution enables connected and intelligent illumination using cutting-edge and existing networks using Modbus TCP/IP or DALI, allowing operators to control lights and sensors remotely. The status of fixtures can also be monitored remotely with this platform reducing maintenance and downtimes.
This lightweight low-profile explosion proof LED is compact and built with extruded aluminum. The fixture is Marine approved and NEMA 4X and IP67 rated, making it dust-proof and protected against high pressure jets and temporary submersion, as well as resistant to vibration and impacts.
The EPL-ANC-48-2L-LED is offered with suspension pendant mounting or surface mounting options. This light is universal voltage and can operate on any voltage from 120V to 277V AC 50/60Hz without modifications. There is no ballast in this unit and the included LED lamps have a 50,000+ hour service life, both of which result in extreme efficiency and greatly reduced maintenance costs.
“This LED fixture provides reliable, durable and safe power to hazardous locations, with maximum efficiency due to the third generation LEDs, and reliable network connectivity,” said Rob Bresnahan, CEO of Larson Electronics LLC. “The Modbus network capability allows operators to setup various control and configurations including remote access.”
*About Larson Electronics LLC:* Larson Electronics LLC is a manufacturer of industrial lighting equipment and accessories. The company offers an extensive catalog of industry-grade lighting and power distribution products for the following sectors: manufacturing, construction, food processing, oil and gas, military, marine and automobile. Customers can benefit from the company’s hands-on, customized approach to lighting solutions. Larson Electronics provides expedited service for quotes, customer support and shipments.
*For further information, please contact:*
Rob Bresnahan, *President and CEO
*Toll-free: 1-800-369-6671
Phone: 214-616-6180
Fax: 903-498-3364
E-mail: sales@larsonelectronics.com
Photos accompanying this announcement are available at
http://www.globenewswire.com/NewsRoom/AttachmentNg/4cd8c1c4-4d5c-4a91-90bc-222677c49027
http://www.globenewswire.com/NewsRoom/AttachmentNg/a74556f4-1626-457b-8428-044037b0407f
Reported by GlobeNewswire 22 hours ago.
↧
The Aquabike: Modern Fitness Equipment for All Ages & Fitness Levels
The main goal of the aquabike workout is to provide individuals of all ages with a low-impact, high-intensity water-based exercise regimen. AquaNess by Wike-Up! is an ergonomic device which combines the incredible benefits of water resistance with traditional cycling.
MIAMI (PRWEB) August 31, 2018
There are many types of exercises that prove to be problematic for individuals due to their impact on joints and increased chance of injury. HIIT, weight-lifting and running, while all beneficial types of exercise, are not a feasible workout for those rehabbing an injury or just generally less physically fit. Individuals who are very overweight may have the desire to exercise and lose weight, but find many popular, high-intensity workouts are just too strenuous on their bodies when just starting out. Aquabiking is the perfect way to jump back into a solid exercise routine with quick results, with the least chance of increased injury or pain.
Aquabiking offers a variety of benefits. It’s an impactful piece of workout equipment suitable for everyone, and also highly recommended by medical sector. Here are some reasons why:· An Easy & Safe Sport
While only putting forth a 12th of the effort when compared to traditional cycling, individuals are still getting the same results when they exercise. Water workouts allow to only feel ⅓ of your body weight. In addition, aquabiking is a low-impact workout, so it’s much easier for those individuals with fragile joints. It also aids those who can only engage in a low-impact exercise.
· Improve your Cardiovascular System
Traditional cycling can be very strenuous, so it may not be easy to exert that level of energy for a long period of time. When you incorporate water resistance, you can sustain this type of exercise for a longer period of time, therefore increasing the benefits. Aquabiking basically equals better results with less effort!
· Keep those Pesky Pounds off the Waistline
People will be able to burn anywhere from 300-to-500 calories in just 30 minutes when aquabiking. In addition to a quick calorie burn with less effort, aquabiking offers a full-body workout, making it necessary to set aside additional time to work on abs, arms, legs, etc.
· Perfect for Individuals Rehabbing an Injury
The low-impact nature of water provides a faster recovery for knees, hips, and other extremities. While your body recovers, continue to work out at a comfortable pace and slowly increase the intensity as you start to feel better. This helps your muscles regain strength and mobility in a safe way as you work towards recovery.
Whether you are trying to stay in shape, create a regular exercise regimen, rehabilitate an injury, train for an athletic event, or just relax after a long day, Wike-Up! Aquabike combines multiple fitness benefits, and offers af full body workout with less risk of injuries. The Aquabike is typically used in private pools, but is also a key piece of equipment utilized by city recreation centers, sport & medical facilities, communities, and hotel resorts.
Additionally, AquaNess by Wike-Up! water bike is the lightest and strongest fitness equipment on the market, starting at 18lbs. All aquabikes are made from marine aluminum and offer a unique combination of benefits such as lightness, mechanical resistance and high corrosion resistance in salt and chlorinated water. The main benefit is to lift in and lift out the pool without difficulties.
AquaNess by Wike-Up! is defined by two different kind of aquabikes:· The Fitness models are perfect for the passive exerciser that may have particular fitness restrictions or are just starting out with a new exercise routine. The Fitness Aquabike range has an adjustable blade resistance. The more they are spread apart in the water, the more the resistance will increase. In addition, the Fitness Plus model has an adjustable positions options and has neoprene pedals like the Performance range.
· The Performance models are perfect for aspiring or professional athletes with deeply-rooted sports-related exercise regimens. The Performance range proposes an adjustable resistance with a regulated braking system. Unlike the Performance model, the Performance Plus model can adjust the position and height of it saddle, and the height of its handlebar and feet. Reported by PRWeb 21 hours ago.
MIAMI (PRWEB) August 31, 2018
There are many types of exercises that prove to be problematic for individuals due to their impact on joints and increased chance of injury. HIIT, weight-lifting and running, while all beneficial types of exercise, are not a feasible workout for those rehabbing an injury or just generally less physically fit. Individuals who are very overweight may have the desire to exercise and lose weight, but find many popular, high-intensity workouts are just too strenuous on their bodies when just starting out. Aquabiking is the perfect way to jump back into a solid exercise routine with quick results, with the least chance of increased injury or pain.
Aquabiking offers a variety of benefits. It’s an impactful piece of workout equipment suitable for everyone, and also highly recommended by medical sector. Here are some reasons why:· An Easy & Safe Sport
While only putting forth a 12th of the effort when compared to traditional cycling, individuals are still getting the same results when they exercise. Water workouts allow to only feel ⅓ of your body weight. In addition, aquabiking is a low-impact workout, so it’s much easier for those individuals with fragile joints. It also aids those who can only engage in a low-impact exercise.
· Improve your Cardiovascular System
Traditional cycling can be very strenuous, so it may not be easy to exert that level of energy for a long period of time. When you incorporate water resistance, you can sustain this type of exercise for a longer period of time, therefore increasing the benefits. Aquabiking basically equals better results with less effort!
· Keep those Pesky Pounds off the Waistline
People will be able to burn anywhere from 300-to-500 calories in just 30 minutes when aquabiking. In addition to a quick calorie burn with less effort, aquabiking offers a full-body workout, making it necessary to set aside additional time to work on abs, arms, legs, etc.
· Perfect for Individuals Rehabbing an Injury
The low-impact nature of water provides a faster recovery for knees, hips, and other extremities. While your body recovers, continue to work out at a comfortable pace and slowly increase the intensity as you start to feel better. This helps your muscles regain strength and mobility in a safe way as you work towards recovery.
Whether you are trying to stay in shape, create a regular exercise regimen, rehabilitate an injury, train for an athletic event, or just relax after a long day, Wike-Up! Aquabike combines multiple fitness benefits, and offers af full body workout with less risk of injuries. The Aquabike is typically used in private pools, but is also a key piece of equipment utilized by city recreation centers, sport & medical facilities, communities, and hotel resorts.
Additionally, AquaNess by Wike-Up! water bike is the lightest and strongest fitness equipment on the market, starting at 18lbs. All aquabikes are made from marine aluminum and offer a unique combination of benefits such as lightness, mechanical resistance and high corrosion resistance in salt and chlorinated water. The main benefit is to lift in and lift out the pool without difficulties.
AquaNess by Wike-Up! is defined by two different kind of aquabikes:· The Fitness models are perfect for the passive exerciser that may have particular fitness restrictions or are just starting out with a new exercise routine. The Fitness Aquabike range has an adjustable blade resistance. The more they are spread apart in the water, the more the resistance will increase. In addition, the Fitness Plus model has an adjustable positions options and has neoprene pedals like the Performance range.
· The Performance models are perfect for aspiring or professional athletes with deeply-rooted sports-related exercise regimens. The Performance range proposes an adjustable resistance with a regulated braking system. Unlike the Performance model, the Performance Plus model can adjust the position and height of it saddle, and the height of its handlebar and feet. Reported by PRWeb 21 hours ago.
↧
Routine Traffic Stop Leads Police to Discover 70 Shrapnel-Laced Pipe Bombs in Ex-Marine's Home
During a traffic stop Police discovered bomb-making components in the vehicle of a 51-year-old former Marine.
Reported by eBaums World 20 hours ago.
↧
The world’s smallest dive system launches on Kickstarter
A device that allows users to breathe underwater without SCUBA tanks has launched on the crowdfunding platform, Kickstarter. NEMO by BLU3 is a portable and easy-to-use dive system.
POMPANO BEACH, Fla. (PRWEB) August 31, 2018
Today, BLU3 is proud to announce the next generation of diving has launched on the crowdfunding platform, Kickstarter. NEMO by BLU3 is a portable and easy-to-use dive system that allows users to breathe underwater without the use of tanks. The campaign launched in the early morning and was over 50% funded within the first 7 hours.
The company defines NEMO as an incredibly compact Surface-Supplied Air (SSA) dive system that supports one diver to 10 feet – bridging the gap between snorkeling and SCUBA diving. BLU3’s goal is to make the sport of diving more accessible, in an effort to increase awareness of the world’s underwater environments.
“The more people who experience the underwater world, the more people that might help protect it,” stated Blake Carmichael, founder and CEO of BLU3.
NEMO’s biggest draw is portability, the product spans less than 12 inches on all sides and weighs in at a surprisingly light 10 pounds, it is about the size of an American football, rugby ball, or two-slice toaster.
In addition to being compact and easy-to-use, each NEMO comes with a comprehensive training course to ensure the safety of both consumers and underwater environments. BLU3 also plans to add an interactive and educational page to the company website before products are delivered later this year.
Fans of the product have reached out to the company expressing anticipation of NEMO for use in various ways – from treasure hunting and pool entertainment to aquatic therapy and boat maintenance. “Whether you're an ocean explorer, poolside parent, treasure hunter, underwater photographer, boat owner, or in search of the latest yacht toy – NEMO is for you,” said inventor John Colborn.
NEMO will be available in a vibrant blue foam and reflective green tube for maximum visibility on the water. If the funding goal is surpassed by a certain amount, the tube will also be available in a lively pink color.
Inside NEMO's buoyant foam and tube is a custom battery-powered air compressor. The compressor pumps air to the diver through the 10-foot hose and out through NEMO's patent-pending Smart Reg™ all of which is powered by a single battery.
Specs:
Capacity: 1 Diver
Depth: 10 feet
Run time: 60+ minutes
Dimensions: 11” x 7.5” x 8”
Weight: ~10 lb.
Battery: Lithium Ion battery pack
Fast and easy replacement for all day diving
3-hour charge time
About BLU3:
BLU3 develops and manufactures ultra-portable diving systems with the mission to increase protection and awareness of underwater environments by spreading the sport of diving. The small company has been supported by Brownie’s Marine Group, an innovative family of brands with a unique concentration on the diving industry, best known for its flagship product Brownie’s Third Lung. BLU3 is a wholly owned subsidiary of Brownie’s Marine Group. For investment opportunities please visit browniesmarinegroup.com/investors
For more information about BLU3, visit the NEMO campaign on Kickstarter or diveblu3.com. Reported by PRWeb 19 hours ago.
POMPANO BEACH, Fla. (PRWEB) August 31, 2018
Today, BLU3 is proud to announce the next generation of diving has launched on the crowdfunding platform, Kickstarter. NEMO by BLU3 is a portable and easy-to-use dive system that allows users to breathe underwater without the use of tanks. The campaign launched in the early morning and was over 50% funded within the first 7 hours.
The company defines NEMO as an incredibly compact Surface-Supplied Air (SSA) dive system that supports one diver to 10 feet – bridging the gap between snorkeling and SCUBA diving. BLU3’s goal is to make the sport of diving more accessible, in an effort to increase awareness of the world’s underwater environments.
“The more people who experience the underwater world, the more people that might help protect it,” stated Blake Carmichael, founder and CEO of BLU3.
NEMO’s biggest draw is portability, the product spans less than 12 inches on all sides and weighs in at a surprisingly light 10 pounds, it is about the size of an American football, rugby ball, or two-slice toaster.
In addition to being compact and easy-to-use, each NEMO comes with a comprehensive training course to ensure the safety of both consumers and underwater environments. BLU3 also plans to add an interactive and educational page to the company website before products are delivered later this year.
Fans of the product have reached out to the company expressing anticipation of NEMO for use in various ways – from treasure hunting and pool entertainment to aquatic therapy and boat maintenance. “Whether you're an ocean explorer, poolside parent, treasure hunter, underwater photographer, boat owner, or in search of the latest yacht toy – NEMO is for you,” said inventor John Colborn.
NEMO will be available in a vibrant blue foam and reflective green tube for maximum visibility on the water. If the funding goal is surpassed by a certain amount, the tube will also be available in a lively pink color.
Inside NEMO's buoyant foam and tube is a custom battery-powered air compressor. The compressor pumps air to the diver through the 10-foot hose and out through NEMO's patent-pending Smart Reg™ all of which is powered by a single battery.
Specs:
Capacity: 1 Diver
Depth: 10 feet
Run time: 60+ minutes
Dimensions: 11” x 7.5” x 8”
Weight: ~10 lb.
Battery: Lithium Ion battery pack
Fast and easy replacement for all day diving
3-hour charge time
About BLU3:
BLU3 develops and manufactures ultra-portable diving systems with the mission to increase protection and awareness of underwater environments by spreading the sport of diving. The small company has been supported by Brownie’s Marine Group, an innovative family of brands with a unique concentration on the diving industry, best known for its flagship product Brownie’s Third Lung. BLU3 is a wholly owned subsidiary of Brownie’s Marine Group. For investment opportunities please visit browniesmarinegroup.com/investors
For more information about BLU3, visit the NEMO campaign on Kickstarter or diveblu3.com. Reported by PRWeb 19 hours ago.
↧
↧
Researchers Turning To Deadly Venoms In Quests For Life-Saving Therapies
Venomous reptiles, bugs and marine life have notorious reputations as dangerous, sometimes life-threatening creatures.
But in a paper in the current issue of Science, first author Mandë Holford, an associate professor of chemistry and biochemistry at The Graduate Center of The City University of New York (GC/CUNY) and Hunter College, details how technology and a growing understanding of the evolution of venoms are pointing the way toward entirely new classes of drugs capable of treating diabetes, autoimmune diseases, chronic pain, and other conditions.
According to Holford and her colleagues, venomous species account for more than 15 percent of the Earth’s documented biodiversity, and they can be found in virtually all marine and terrestrial habitats. Still, researchers have studied very few venoms because until recently they lacked the appropriate technology for analyzing the tiny amounts of venom that can be extracted from these mostly small species. But innovations in omics (technologies that map the roles, relationships, and actions of an organism’s molecular structure) are allowing researchers to uncover evolutionary changes and diversification among specific venomous species that could prove useful in developing new drugs capable of precisely targeting and binding to molecules that are active in certain human diseases.
“Knowing more about the evolutionary history of venomous species can help us make more targeted decisions about the potential use of venom compounds in treating illnesses,” said Holford. “New environments, the development of venom resistance in its prey, and other factors can cause a species to evolve in order to survive. These changes can produce novel compounds — some of which may prove extremely useful in drug development.”
To date, only six Food and Drug Administration-approved, venom-derived drugs have been developed as a result of modern-day research, but Holford and her colleagues believe greater investment in venom research could yield therapies for currently untreatable diseases as well as improved therapeutic options.
Potential drug advances include therapeutic peptides derived from the venomous sea anemone, which researchers believe could treat autoimmune diseases; therapeutic neurotoxins derived from the Conus magus, which scientists think could provide non-addictive treatment of chronic pain; chlorotoxin from the deathstalker scorpion, which could be the basis for a surgical tumor-imaging technique; and spider toxins, which could yield ecofriendly insecticides.
Holford and her follow authors conclude that an evolution-informed perspective will help focus venom research so that it can leverage the extraordinary biochemical warfare created by nature to yield transformative therapeutics and bio-insecticides. Reported by Eurasia Review 18 hours ago.
But in a paper in the current issue of Science, first author Mandë Holford, an associate professor of chemistry and biochemistry at The Graduate Center of The City University of New York (GC/CUNY) and Hunter College, details how technology and a growing understanding of the evolution of venoms are pointing the way toward entirely new classes of drugs capable of treating diabetes, autoimmune diseases, chronic pain, and other conditions.
According to Holford and her colleagues, venomous species account for more than 15 percent of the Earth’s documented biodiversity, and they can be found in virtually all marine and terrestrial habitats. Still, researchers have studied very few venoms because until recently they lacked the appropriate technology for analyzing the tiny amounts of venom that can be extracted from these mostly small species. But innovations in omics (technologies that map the roles, relationships, and actions of an organism’s molecular structure) are allowing researchers to uncover evolutionary changes and diversification among specific venomous species that could prove useful in developing new drugs capable of precisely targeting and binding to molecules that are active in certain human diseases.
“Knowing more about the evolutionary history of venomous species can help us make more targeted decisions about the potential use of venom compounds in treating illnesses,” said Holford. “New environments, the development of venom resistance in its prey, and other factors can cause a species to evolve in order to survive. These changes can produce novel compounds — some of which may prove extremely useful in drug development.”
To date, only six Food and Drug Administration-approved, venom-derived drugs have been developed as a result of modern-day research, but Holford and her colleagues believe greater investment in venom research could yield therapies for currently untreatable diseases as well as improved therapeutic options.
Potential drug advances include therapeutic peptides derived from the venomous sea anemone, which researchers believe could treat autoimmune diseases; therapeutic neurotoxins derived from the Conus magus, which scientists think could provide non-addictive treatment of chronic pain; chlorotoxin from the deathstalker scorpion, which could be the basis for a surgical tumor-imaging technique; and spider toxins, which could yield ecofriendly insecticides.
Holford and her follow authors conclude that an evolution-informed perspective will help focus venom research so that it can leverage the extraordinary biochemical warfare created by nature to yield transformative therapeutics and bio-insecticides. Reported by Eurasia Review 18 hours ago.
↧
'The Predator' Debuts Final Red Band Trailer - Watch Now!
The Predator just debuted its final trailer before its release next month and you need to see it! The new red band trailer shows plenty of human vs. predator action as a group takes on an Alpha Predator. The flick follows a former Army ranger who joins forces with a former Marine and his predator-hunting [...]
Reported by Just Jared 15 hours ago.
↧
Meet the Hottest US Marine Ever (PHOTOS)
Reported by RIA Nov. 11 hours ago.
↧
Larson Electronics Releases Explosion Proof Weatherproof Horn with Programmable Timer
KEMP, Texas, Sept. 01, 2018 (GLOBE NEWSWIRE) -- Larson Electronics LLC, a leader in the industrial lighting sector, announced the release of a brand-new explosion proof horn with a programmable timer. This weatherproof industrial siren offers a powerful audible alarm system ideal for rugged industrial environments.The EPSN-HRN-PA-AT-MOD1 is an explosion proof alert/signal system that can be heard over loud industrial machinery. The siren has 9 different tone options and reaches a peak output of 110dBA. The horn can be remotely operated for priority alerts and includes a programmable timer that ensures accurate automated operation once per hour from 6:30am to 5:30pm.
Tones options include: continuous run of eight sounds in sequence, a conventional siren wail, a rapid siren yelp, two-tone, a low to high ascending whoop, a high to low descending yeow, a steady horn, a slow intermittent beep and a rapid intermittent stutter. An additional “remote” function allows the selection between horn, alternating two-tone, rapid yelp and a manual siren wail.
The EPSN-HRN-PA-AT-MOD1 is weatherproof and dustproof, as well as NEMA 4X rated. The housing is constructed of heavy-duty aluminum, and the horn component is engineered with fiberglass. A durable grey powder coat provides resistance to corrosion and makes this unit wet environment approved. This horn has an omni-directional bracket allowing it to be mounted on flat surfaces with vertical adjustment.
“Working in locations where machinery is loud makes it difficult to find an effective audible emergency notification system,” said Rob Bresnahan, CEO of Larson Electronics. “This explosion proof siren is a powerful system for operators in loud and rugged industrial environments.”
*About Larson Electronics LLC:* Larson Electronics LLC is a manufacturer of industrial lighting equipment and accessories. The company offers an extensive catalog of industry-grade lighting and power distribution products for the following sectors: manufacturing, construction, food processing, oil and gas, military, marine and automobile. Customers can benefit from the company’s hands-on, customized approach to lighting solutions. Larson Electronics provides expedited service for quotes, customer support and shipments.
*For further information, please contact:*
Rob Bresnahan, *President and CEO
*Toll-free: 1-800-369-6671
Phone: 214-616-6180
Fax: 903-498-3364
E-mail: sales@larsonelectronics.com
A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/044357e7-68a5-449d-9d3b-71c80b5ded9c Reported by GlobeNewswire 3 hours ago.
Tones options include: continuous run of eight sounds in sequence, a conventional siren wail, a rapid siren yelp, two-tone, a low to high ascending whoop, a high to low descending yeow, a steady horn, a slow intermittent beep and a rapid intermittent stutter. An additional “remote” function allows the selection between horn, alternating two-tone, rapid yelp and a manual siren wail.
The EPSN-HRN-PA-AT-MOD1 is weatherproof and dustproof, as well as NEMA 4X rated. The housing is constructed of heavy-duty aluminum, and the horn component is engineered with fiberglass. A durable grey powder coat provides resistance to corrosion and makes this unit wet environment approved. This horn has an omni-directional bracket allowing it to be mounted on flat surfaces with vertical adjustment.
“Working in locations where machinery is loud makes it difficult to find an effective audible emergency notification system,” said Rob Bresnahan, CEO of Larson Electronics. “This explosion proof siren is a powerful system for operators in loud and rugged industrial environments.”
*About Larson Electronics LLC:* Larson Electronics LLC is a manufacturer of industrial lighting equipment and accessories. The company offers an extensive catalog of industry-grade lighting and power distribution products for the following sectors: manufacturing, construction, food processing, oil and gas, military, marine and automobile. Customers can benefit from the company’s hands-on, customized approach to lighting solutions. Larson Electronics provides expedited service for quotes, customer support and shipments.
*For further information, please contact:*
Rob Bresnahan, *President and CEO
*Toll-free: 1-800-369-6671
Phone: 214-616-6180
Fax: 903-498-3364
E-mail: sales@larsonelectronics.com
A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/044357e7-68a5-449d-9d3b-71c80b5ded9c Reported by GlobeNewswire 3 hours ago.
↧
↧
Larson Electronics LLC Releases 50’ 12/3 SOOW Twist Lock Extension Power Cord
KEMP, Texas, Sept. 01, 2018 (GLOBE NEWSWIRE) -- Industrial lighting leader, Larson Electronics, has announced the release of a brand new 50 foot 12/3 SOOW extension power cord equipped with a 20-amp rated NEMA L5-20P male and L5-20C female twist lock connector. This extension cord is designed for heavy duty applications, allowing operators to extend power to for maintenance, power generator operation, construction equipment and other temporary applications.The EXC-50-12.3-20A-L5.20P-L5.20C is a rugged extension cord constructed of 12/3 SOOW cable terminated in a male NEMA L5-20P and female NEMA L5-20C, 20 amp rated, outdoor approved twist lock cord caps. This 50-foot SOOW extension cord is flexible and chemical and abrasion resistant. Operators can use this cord to power their 125V equipment from just a single system. This industrial extensor cord is popular for use in remote outdoor locations to connect generators, stage equipment, UPS battery backups and other industrial equipment.
“This SOOW extension cord is ideal for operators who need to extend 125-volt power to their equipment in a remote location where regular outlets are unavailable,” said Rob Bresnahan, CEO of Larson Electronics LLC. “The cord is built for use indoors and outdoors for plant turnarounds, exhibits, stage equipment and shipyard applications.”
*About Larson Electronics LLC:* Larson Electronics LLC is a manufacturer of industrial lighting equipment and accessories. The company offers an extensive catalog of industry-grade lighting and power distribution products for the following sectors: manufacturing, construction, food processing, oil and gas, military, marine and automobile. Customers can benefit from the company’s hands-on, customized approach to lighting solutions. Larson Electronics provides expedited service for quotes, customer support and shipments.
*For further information, please contact:*
Rob Bresnahan, *President and CEO
*Toll-free: 1-800-369-6671
Phone: 214-616-6180
Fax: 903-498-3364
E-mail: sales@larsonelectronics.com
A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/19a09c6f-19cd-42a1-84d7-812fc18bb611 Reported by GlobeNewswire 22 hours ago.
“This SOOW extension cord is ideal for operators who need to extend 125-volt power to their equipment in a remote location where regular outlets are unavailable,” said Rob Bresnahan, CEO of Larson Electronics LLC. “The cord is built for use indoors and outdoors for plant turnarounds, exhibits, stage equipment and shipyard applications.”
*About Larson Electronics LLC:* Larson Electronics LLC is a manufacturer of industrial lighting equipment and accessories. The company offers an extensive catalog of industry-grade lighting and power distribution products for the following sectors: manufacturing, construction, food processing, oil and gas, military, marine and automobile. Customers can benefit from the company’s hands-on, customized approach to lighting solutions. Larson Electronics provides expedited service for quotes, customer support and shipments.
*For further information, please contact:*
Rob Bresnahan, *President and CEO
*Toll-free: 1-800-369-6671
Phone: 214-616-6180
Fax: 903-498-3364
E-mail: sales@larsonelectronics.com
A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/19a09c6f-19cd-42a1-84d7-812fc18bb611 Reported by GlobeNewswire 22 hours ago.
↧
Sea Anemones Could Help Fight Alzheimer’s Disease
Heteractis magnifica sea anemones contain neuroprotective peptides that slow down the inflammation process and the deterioration of neurons in the development of Alzheimer’s. There is currently no treatment against this disease, Phys.org reports.
The Kunitz-type peptide HMIQ3c1was synthesized by scientists in a bacterial system (Escherichia coli) and is a recombinant analog of the peptide contained in the tentacles of tropical sea anemones Heteractis magnifica—marine sediment dwellers of the class Anthozoa. The sea anemones were collected near the Seychelles during a scientific marine expedition at the Akademik Oparin scientific and research ship. Genetic studies revealed a new group of Kunitz-type peptides in the sea anemone. Using the structure of the gene coding of one such peptide, a scientific team synthesized this peptide’s artificial analog in the lab of G.A. Belyakov Pacific Institute of Bioorganic Chemistry.
The synthesized peptide belongs to the new group of IQ-peptides that named after two first amino acid residues—isoleucine (I) and glutamine (Q). The substance has neuroprotective properties. Therefore, HMIQ3c1 inhibits the development of inflammation, including that fitting the Alzheimer’s model. Patients with Alzheimer’s disease are subject to various neurological disorders, including disorientation and memory loss. The peptide was tested in the lab on the cells of mouse neuroblastoma. It reduced the levels of active oxygen forms that cause cell damage. Such forms usually appear after a cell is influenced by the neurotoxin 6-hydroxydopamine, causing neuron death. The same mechanism is observed in human cells.
“While the inflammation process is a normal reaction of a body to any injury, infection, or other external influence, chronic inflammation can cause many serious disorders—not only the Alzheimer’s, but also Parkinson’s disease, arthritis, pancreatitis, cancer, and other diseases. Proteases are ferments that destroy proteins. They play an important role in the inflammation process, and are therefore among the most desired targets for new anti-inflammatory medicinal drugs,” explains Elena Leychenko, a senior research associate at PIBOC (the Far Eastern Department of the Russian Academy of Sciences), assistant professor, and lecturer at the chair of bioorganic chemistry and biotechnology of the School of Natural Sciences, FEFU.
The search for chemical compounds to prevent neuron death is an important task for science and medicine. Inhibitors of protease have been found in the bodies of many marine invertebrates and mammals. Kunitz-type inhibitors are of utmost interest for the scientists as they are not only able to block the destructive ferments but also to react with various receptors and ionic channels. This makes Kunitz-type inhibitors polyfunctional. They can influence several therapeutic targets at once and solve different tasks simultaneously depending on the circumstances.
Sea anemones are a rich source of such inhibitors. In their previous work, the scientists from FEFU-PIBOC discovered protease inhibitors in Heteractis crispa. The peptides found in H. crispa, as well as the newly discovered peptides from H. magnifica form combinatorial libraries and possess considerable pharmacological potential. Peptides from these libraries have similar structures and, as a rule, one main function. At the same time, chemical compounds from one library can acquire new functions or change (increase or decrease) their main function due to minor structural differences.
“Sea anemones contain a wide range of biological substances with not only neuroprotective but also anti-cancer properties,” says Elena Leychenko. “However, protective properties of these substances and the combinations in which they would work properly require additional studies. The manufacture of new generation drugs may be started only after the completion of all trial stages, including pre- and clinical ones. And this requires extensive funding. If the funds are found, the process would still take 3 to 5 years”.
Peptides are chemical compounds that consist of amino acids with high physiological activity allowing them to regulate various biological processes. Peptides are usually divided into several groups by their bioregulatory properties. However, this division is quite arbitrary as many peptides are polyfunctional, i.e. their activity is not limited to one target. Reported by Eurasia Review 18 hours ago.
The Kunitz-type peptide HMIQ3c1was synthesized by scientists in a bacterial system (Escherichia coli) and is a recombinant analog of the peptide contained in the tentacles of tropical sea anemones Heteractis magnifica—marine sediment dwellers of the class Anthozoa. The sea anemones were collected near the Seychelles during a scientific marine expedition at the Akademik Oparin scientific and research ship. Genetic studies revealed a new group of Kunitz-type peptides in the sea anemone. Using the structure of the gene coding of one such peptide, a scientific team synthesized this peptide’s artificial analog in the lab of G.A. Belyakov Pacific Institute of Bioorganic Chemistry.
The synthesized peptide belongs to the new group of IQ-peptides that named after two first amino acid residues—isoleucine (I) and glutamine (Q). The substance has neuroprotective properties. Therefore, HMIQ3c1 inhibits the development of inflammation, including that fitting the Alzheimer’s model. Patients with Alzheimer’s disease are subject to various neurological disorders, including disorientation and memory loss. The peptide was tested in the lab on the cells of mouse neuroblastoma. It reduced the levels of active oxygen forms that cause cell damage. Such forms usually appear after a cell is influenced by the neurotoxin 6-hydroxydopamine, causing neuron death. The same mechanism is observed in human cells.
“While the inflammation process is a normal reaction of a body to any injury, infection, or other external influence, chronic inflammation can cause many serious disorders—not only the Alzheimer’s, but also Parkinson’s disease, arthritis, pancreatitis, cancer, and other diseases. Proteases are ferments that destroy proteins. They play an important role in the inflammation process, and are therefore among the most desired targets for new anti-inflammatory medicinal drugs,” explains Elena Leychenko, a senior research associate at PIBOC (the Far Eastern Department of the Russian Academy of Sciences), assistant professor, and lecturer at the chair of bioorganic chemistry and biotechnology of the School of Natural Sciences, FEFU.
The search for chemical compounds to prevent neuron death is an important task for science and medicine. Inhibitors of protease have been found in the bodies of many marine invertebrates and mammals. Kunitz-type inhibitors are of utmost interest for the scientists as they are not only able to block the destructive ferments but also to react with various receptors and ionic channels. This makes Kunitz-type inhibitors polyfunctional. They can influence several therapeutic targets at once and solve different tasks simultaneously depending on the circumstances.
Sea anemones are a rich source of such inhibitors. In their previous work, the scientists from FEFU-PIBOC discovered protease inhibitors in Heteractis crispa. The peptides found in H. crispa, as well as the newly discovered peptides from H. magnifica form combinatorial libraries and possess considerable pharmacological potential. Peptides from these libraries have similar structures and, as a rule, one main function. At the same time, chemical compounds from one library can acquire new functions or change (increase or decrease) their main function due to minor structural differences.
“Sea anemones contain a wide range of biological substances with not only neuroprotective but also anti-cancer properties,” says Elena Leychenko. “However, protective properties of these substances and the combinations in which they would work properly require additional studies. The manufacture of new generation drugs may be started only after the completion of all trial stages, including pre- and clinical ones. And this requires extensive funding. If the funds are found, the process would still take 3 to 5 years”.
Peptides are chemical compounds that consist of amino acids with high physiological activity allowing them to regulate various biological processes. Peptides are usually divided into several groups by their bioregulatory properties. However, this division is quite arbitrary as many peptides are polyfunctional, i.e. their activity is not limited to one target. Reported by Eurasia Review 18 hours ago.
↧
Why Diesel Prices Are Set To Soar
The world is ticking down to a deadline that promises to have major ramifications in the global fuel markets. On January 1, 2020, the International Maritime Organization (IMO) will require the sulfur content in marine fuel to drop from a maximum of 3.5 percent down to 0.5 percent. The rule is meant to curb pollution from ships. Combustion of high-sulfur fuels leads to the production of compounds like sulfur dioxide, which causes respiratory problems and produces acid rain. This rule continues a trend of limiting the sulfur content in…
Reported by OilPrice.com 13 hours ago.
↧
